Printable page in A4 size Matthew C.L. Phillips
Waikato Hospital · Neurology Department
"Metabolic Strategies in Healthcare: A New Era"
Abstract
Disease-centric Medicine
Modern healthcare systems are founded on a disease-centric paradigm, which has conferred many notable successes against infectious disorders in the past. Our disease-centric paradigm regards these disorders as distinct disease processes, caused and driven by disease targets that must be suppressed or eliminated to clear the disease.
Health-centric Medicine
Today’s leading causes of death are dominated by non-infectious “lifestyle” disorders, broadly represented by the metabolic syndrome, atherosclerosis, cancer, and neurodegeneration. By contrast, a health-centric paradigm recognizes the lifestyle disorders as a series of hormonal and metabolic responses to a singular, lifestyle-induced disease of mitochondria dysfunction, a disease target that must be restored to improve health, which may be defined as optimized mitochondria function.
Metabolic Strategies Restore Health
Seen from a health-centric perspective, most drugs target a response rather than the disease, whereas metabolic strategies, such as fasting and carbohydrate-restricted diets, aim to restore mitochondria function, mitigating the impetus that underlies and drives the lifestyle disorders.
Evidence in New Science
Substantial human evidence indicates either strategy can effectively mitigate the metabolic syndrome.
Preliminary evidence also indicates potential benefits in atherosclerosis, cancer, and neurodegeneration.
Given the existing evidence, integrating metabolic strategies into modern healthcare systems should be identified as a global health priority.
"Metabolic Strategies in Healthcare: A New Era"
(35 minutes)
Matthew C.L. Phillips - 15 July 2022
"Metabolic Strategies in Healthcare: A New Era" The Paper
You can read and print the paper here. (18 Pages)
The texts below link to most of the papers cited by Matthew C.L. Phillips, in the above paper.
Introduction
Mitochondrial dysfunction in metabolic syndrome - PubMed
2020
By Pankaj Prasun
Mitochondrial Dysfunction in Atherosclerosis
July, 2019
By Wenxi Peng, Guoding Cai, Yiping Xia, Jinna Chen, Peng Wu, Zuo Wang, Guohua Li, and Dangheng Wei
Mitochondrial DNA damage and atherosclerosis
2014, July
By Emma P K Yu, Martin R Bennett
Electron microscopy morphology of the mitochondrial network in human cancer
October, 2009
By Arismendi-Morillo, Gabriel
Cancer as a metabolic disease: implications for novel therapeutics
March, 2014
By 
Thomas N Seyfried, Roberto E Flores, Angela M Poff, Dominic P D'Agostino
Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease
November, 2015
By Chris Cadonic, Mohammad Golam Sabbir, Benedict C Albensi
Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches
2018
By Julia R Clarke, Felipe C Ribeiro, Rudimar L Frozza, Fernanda G De Felice, Mychael V Lourenco
2. A Transition in Dietary Lifestyle
Dietary fat: From foe to friend?
November, 2018
By David S Ludwig, Walter C Willett, Jeff S Volek, Marian L Neuhouser
2.1 The Hunter-Gatherer Dietary Lifestyle
Current views on hunter-gatherer nutrition and the evolution of the human diet
January, 2017
By Alyssa N. Crittenden, Stephanie L. Schnorr
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
March, 2010
By Michael Ristow, Kim Zarse
Intermittent metabolic switching, neuroplasticity and brain health
April, 2018
By Mark P Mattson, Keelin Moehl, Nathaniel Ghena, Maggie Schmaedick, Aiwu Cheng
Ketone Bodies, Potential Therapeutic Uses
January, 2008
By Richard L. Veech, Britton Chance, Yoshihiro Kashiwaya, Henry A. Lardy, George F. Cahill Jr
Fiber and Colon Health On A Well-Formulated Ketogenic Diet: New Insights Question Its Role As An Unconditional Requirement
March, 2019
By Stephen Phinney, MD, PhD, Jeff S Volek PhD, RD
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
March, 2020
By Asier González, Michael N Hall, Sheng-Cai Lin, D Grahame Hardie
2.2 The Modern Dietary Lifestyle
Dietary fat: From foe to friend?
November, 2018
By David S Ludwig, Walter C Willett, Jeff S Volek, Marian L Neuhouser
Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes?
September, 2020
By Nordin M J Hanssen, Michael J Kraakman, Michelle C Flynn, Prabhakara R Nagareddy, Casper G Schalkwijk, Andrew J Murphy
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases
January, 20
By Alejandro Gugliucci
The Mitochondrial Response to DNA Damage
May, 2021
By Ziye Rong, Peipei Tu, Peiqi Xu, Yan Sun, Fangfang Yu, Na Tu, Lixia Guo, Yanan Yang
3. Mitochondria Dysfunction: A Singular Disease
3.1 Conflict Between Hyperinsulinemia and Insulin Resistance
Insulin and insulin resistance
May, 2005
By Gisela Wilcox
Insulin resistance: a metabolic pathway to chronic liver disease
November, 2005
By Elisabetta Bugianesi, Arthur J McCullough, Giulio Marchesini
Effect of low-carbohydrate diets on cardiometabolic risk, insulin resistance, and metabolic syndrome
October, 2020
By Blair J O'Neill
3.2 The Metabolic Syndrome
Non-alcoholic fatty liver disease
April, 2021
By Prof Elizabeth E Powell, MD; Prof Vincent Wai-Sun Wong, MD; Prof Mary Rinella, MD
Small, dense low-density-lipoproteins and the metabolic syndrome
January, 2007
By Manfredi Rizzo, Kaspar Berneis
Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes
September, 2019
By Priya Reddy, Daniella Lent-Schochet, Neeraj Ramakrishnan, Matthew McLaughlin, Ishwarlal Jialal
Alzheimer's disease is type 3 diabetes-evidence reviewed
November, 2008
By Suzanne M de la Monte, Jack R Wands
Prediabetes: a high-risk state for diabetes development
June, 2012
By Adam G Tabák, Christian Herder, Wolfgang Rathmann, Eric J Brunner, Mika Kivimäki
Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation
May, 2019
By I Barchetta, F A Cimini, G Ciccarelli, M G Baroni, M G Cavallo
The putative role of mitochondrial dysfunction in hypertension
October, 2007
By Paolo Puddu, Giovanni Maria Puddu, Eleonora Cravero, Susanna De Pascalis, Antonio Muscari
3.3 Atherosclerosis
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
June, 2020 - Note the 2017 statement below.
By a Panel of Authors
Inflammation and atherosclerosis: direct versus indirect mechanisms
January, 2013
By Michael E Rosenfeld
Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel
August, 2017 - Note the 2020 statement above.
By a Panel of Authors
Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines
January, 2009
By Amit Sachdeva, Christopher P Cannon, Prakash C Deedwania, Kenneth A Labresh, Sidney C Smith Jr, David Dai, Adrian Hernandez, Gregg C Fonarow
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review
June, 2016 - Note the 2018 Paper below.
By Uffe Ravnskov, David M Diamond, Rokura Hama, Tomohito Hamazaki, Björn Hammarskjöld, Niamh Hynes, Malcolm Kendrick, Peter H Langsjoen, Aseem Malhotra, Luca Mascitelli, Kilmer S McCully, Yoichi Ogushi, Harumi Okuyama, Paul J Rosch, Tore Schersten, Sherif Sultan, Ralf Sundberg
Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
September, 2016
By Michael G Silverman, Brian A Ference, Kyungah Im, Stephen D Wiviott, Robert P Giugliano, Scott M Grundy, Eugene Braunwald, Marc S Sabatine
LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature
October, 2018 - Note the 2016 Paper above.
By Uffe Ravnskov, Michel de Lorgeril, David M Diamond, Rokuro Hama, Tomohito Hamazaki, Björn Hammarskjöld, Niamh Hynes, Malcolm Kendrick, Peter H Langsjoen, Luca Mascitelli, Kilmer S McCully, Harumi Okuyama, Paul J Rosch, Tore Schersten, Sherif Sultan, Ralf Sundberg
Mitochondrial dysfunction in atherosclerosis
March, 2007
By Nageswara R Madamanchi, Marschall S Runge
Infectious Agents in Atherosclerotic Cardiovascular Diseases through Oxidative Stress
November, 2017
By Marisa Di Pietro, Simone Filardo, Francesca Falasca, Ombretta Turriziani, Rosa Sessa
Mitochondrial dysfunction: a key player in the pathogenesis of cardiovascular diseases linked to air pollution
June, 2018
By Sri Rahavi Boovarahan, Gino A Kurian
High cholesterol may protect against infections and atherosclerosis
December, 2003
By U Ravnskov
3.4 Cancer
Hallmarks of cancer: the next generation
March, 2011
By Douglas Hanahan, Robert A Weinberg
Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris
January, 2008
By Theodor Boveri
Otto Warburg's contributions to current concepts of cancer metabolism
May, 2011
By Willem H Koppenol, Patricia L Bounds, Chi V Dang
Mitochondrial uncoupling in cancer cells: Liabilities and opportunities
August, 2017
By Gyorgy Baffy
The living state and cancer.
July, 1977
By A Szent-Györgyi
Full Text Open Access Article - Printable images of original article.
Cancer as a mitochondrial metabolic disease
July, 2015
On the origin of cancer cells
February, 1956
By O WARBURG
Abstract Only Image of the first page only.
Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics
November, 2013
By Manti Guha, Narayan G Avadhani
3.5 Neurodegeneration
Environmental risk factors for dementia: a systematic review
October, 2016
By Lewis O J Killin, John M Starr, Ivy J Shiue, Tom C Russ
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease
July,
By Joseph L Price, Daniel W McKeel Jr, Virginia D Buckles, Catherine M Roe, Chengjie Xiong, Michael Grundman, Lawrence A Hansen, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Charles D Smith, Daron G Davis, Frederick A Schmitt, William R Markesbery, Jeffrey Kaye, Roger Kurlan, Christine Hulette, Brenda F Kurland, Roger Higdon, Walter Kukull, John C Morris
Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
September, 2014
By Gary P Morris, Ian A Clark, Bryce Vissel
Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review
July, 2020
By Tahereh Farkhondeh, Omid Mehrpour, Fatemeh Forouzanfar, Babak Roshanravan, Saeed Samarghandian
Air pollution, oxidative stress, and Alzheimer's disease
Marvh, 2012
By Paula Valencia Moulton, Wei Yang
Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses
June, 2007
By Hyoung-gon Lee, Xiongwei Zhu, Rudy J Castellani, Akihiko Nunomura, George Perry, Mark A Smith
4. Metabolic Strategies: Restoring Mitochondria Function
4.1 Fasting
Effects of Intermittent Fasting on Health, Aging, and Disease
April, 2020
By Ramy Saad
Abstract Only - Some free access available.
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes
June, 2018
By Elizabeth F Sutton , Robbie Beyl, Kate S Early, William T Cefalu, Eric Ravussin, Courtney M Peterson
Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome
January, 2021
By Michael J. Wilkinson, Emily N.C. Manoogian, Adena Zadourian, Hannah Lo, Savannah Fakhouri, Azarin Shoghi, Xinran Wang, Jason G. Fleischer, Saket Navlakha, Satchidananda Panda, and Pam R. Tauba
Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance
September, 2019
By Kelsey Gabel, Cynthia M Kroeger, John F Trepanowski, Kristin K Hoddy, Sofia Cienfuegos, Faiza Kalam, Krista A Varady
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism
January, 2005
By Leonie K Heilbronn, Steven R Smith, Corby K Martin, Stephen D Anton, Eric Ravussin
Total fasting in the treatment of obesity
January, 1968
By I C Gilliland
Full Text Open Access Article - Images of the original article.
The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women
October, 2013
By Michelle Harvie, Claire Wright, Mary Pegington, Debbie McMullan, Ellen Mitchell, Bronwen Martin, Roy G Cutler, Gareth Evans, Sigrid Whiteside, Stuart Maudsley, Simonetta Camandola, Rui Wang, Olga D Carlson, Josephine M Egan, Mark P Mattson, Anthony Howell
Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet - a randomised controlled trial
Febuary, 2021
By Magnus Holmer, Catarina Lindqvist, Sven Petersson, John Moshtaghi-Svensson, Veronika Tillander, Torkel B Brismar, Hannes Hagström, Per Stål
Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans
July, 2013
By Surabhi Bhutani, Monica C Klempel, Cynthia M Kroeger, John F Trepanowski, Krista A Varady
A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity
September, 2016
By Victoria A Catenacci, Zhaoxing Pan, Danielle Ostendorf, Sarah Brannon, Wendolyn S Gozansky, Mark P Mattson, Bronwen Martin, Paul S MacLean, Edward L Melanson, William Troy Donahoo
Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial
July, 2017
By John F Trepanowski, Cynthia M Kroeger, Adrienne Barnosky, Monica C Klempel, Surabhi Bhutani, Kristin K Hoddy, Kelsey Gabel, Sally Freels, Joseph Rigdon, Jennifer Rood, Eric Ravussin, Krista A Varady
Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial
November, 2013
By Krista A Varady, Surabhi Bhutani, Monica C Klempel, Cynthia M Kroeger, John F Trepanowski, Jacob M Haus, Kristin K Hoddy, Yolian Calvo
Effects of Periodic Fasting on Fatty Liver Index-A Prospective Observational Study
October, 2019
By Stefan Drinda, Franziska Grundler, Thomas Neumann, Thomas Lehmann, Nico Steckhan, Andreas Michalsen, Francoise Wilhelmi de Toledo
Blood Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long-Term Fasting
December, 2020
By Franziska Grundler, Robin Mesnage, Andreas Michalsen, Françoise Wilhelmi de Toledo
Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males
October, 2016
By Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri, Antonio Paoli
Intermittent Fasting in Cardiovascular Disorders-An Overview
March, 2019
By Bartosz Malinowski, Klaudia Zalewska, Anna Węsierska, Maya M Sokołowska, Maciej Socha, Grzegorz Liczner, Katarzyna Pawlak-Osińska, Michał Wiciński
Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC State-of-the-Art Review
April, 2021
By Salva R Yurista, Cher-Rin Chong, Juan J Badimon, Daniel P Kelly, Rudolf A de Boer, B Daan Westenbrink
Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats
October, 2012
By M Snorek, D Hodyc, V Sedivý, J Durišová, A Skoumalová, J Wilhelm, J Neckář, F Kolář, J Herget
Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery
May, 2014
By Silvia Manzanero, Joanna R Erion, Tomislav Santro, Frederik J Steyn, Chen Chen, Thiruma V Arumugam, Alexis M Stranahan
Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study
Marvh, 2017
By Lars C. Gormsen, MD, PhD,corresponding author, Mads Svart, MD, Henrik Holm Thomsen, MD, Esben Søndergaard, MD, PhD, Mikkel H. Vendelbo, MD, PhD, Nana Christensen, MLS, Lars Poulsen Tolbod, PhD, Hendrik Johannes Harms, PhD, Roni Nielsen, MD, PhD, Henrik Wiggers, MD, PhD, Niels Jessen, MD, PhD, Jakob Hansen, PhD, Hans Erik Bøtker, MD, DMsc, and Niels Møller, MD, DMsc
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients
April, 2019
By Roni Nielsen, Niels Møller, Lars C Gormsen, Lars Poulsen Tolbod, Nils Henrik Hansson, Jens Sorensen, Hendrik Johannes Harms, Jørgen Frøkiær, Hans Eiskjaer, Nichlas Riise Jespersen, Søren Mellemkjaer, Thomas Ravn Lassen, Kasper Pryds, Hans Erik Bøtker, Henrik Wiggers
Fasting and cancer: molecular mechanisms and clinical application
November, 2018
By Alessio Nencioni, Irene Caffa, Salvatore Cortellino, Valter D Longo
Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and meta-analysis
December, 2014
By Mengmeng Lv, Xingya Zhu, Hao Wang, Feng Wang, Wenxian Guan
Safety and Feasability of Muslim Fasting While Receiving Chemotherapy
January, 2014
By Talha Badar
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
April, 2018
By Stephan P Bauersfeld, Christian S Kessler, Manfred Wischnewsky, Annette Jaensch, Nico Steckhan, Rainer Stange, Barbara Kunz, Barbara Brückner, Jalid Sehouli, Andreas Michalsen
Fasting and cancer treatment in humans: A case series report
December, 2009
By Fernando M Safdie, Tanya Dorff, David Quinn, Luigi Fontana, Min Wei, Changhan Lee, Pinchas Cohen, Valter D Longo
ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma
November, 2020
By Martin Voss, Marlies Wagner, Nina von Mettenheim, Patrick N Harter, Katharina J Wenger, Kea Franz, Jörg Bojunga, Manuela Vetter, Ruediger Gerlach, Michael Glatzel, Frank Paulsen, Elke Hattingen, Oliver Baehr, Michael W Ronellenfitsch, Emmanouil Fokas, Detlef Imhoff, Joachim P Steinbach, Claus Rödel, Johannes Rieger
Managing Metastatic Thymoma With Metabolic and Medical Therapy: A Case Report
May, 2020
By Matthew C L Phillips, Deborah K J Murtagh, Sanjay K Sinha, Ben G Moon
Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease
March, 2016
By Stephen C Cunnane, Alexandre Courchesne-Loyer, Valérie St-Pierre, Camille Vandenberghe, Tyler Pierotti, Mélanie Fortier, Etienne Croteau, Christian-Alexandre Castellano
Brain metabolism in health, aging, and neurodegeneration
June, 2017
By Simonetta Camandola, Mark P Mattson
Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment
March, 2016
By Nidia Celeste Horie, Valeria T Serrao, Sharon Sanz Simon, Maria Rita Polo Gascon, Alessandra Xavier Dos Santos, Maria Aquimara Zambone, Marta Merenciana Del Bigio de Freitas, Edecio Cunha-Neto, Emerson Leonildo Marques, Alfredo Halpern, Maria Edna de Melo, Marcio C Mancini, Cintia Cercato
4.2 Carbohydrate-Restricted Diets
Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health
February, 2018
By Vincent J Miller , Frederick A Villamena, Jeff S Volek
Full Text Open Access Article
Abstract Only
Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction
November, 2005
By Jeff S Volek, Richard D Feinman
Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
July, 2020
By Yeo Jin Choi, Sang-Min Jeon, Sooyoung Shin
The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
March, 2018
By Rosemary Huntriss, Malcolm Campbell, Carol Bedwell
Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis
May, 2018
By Emma Sainsbury, Nathalie V Kizirian, Stephanie R Partridge, Timothy Gill, Stephen Colagiuri, Alice A Gibson
Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials
September, 2017
By Yan Meng, Hao Bai, Shijun Wang, Zhaoping Li, Qian Wang, Liyong Chen
Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. A Meta-Analysis
October, 2015
By Jonathan Sackner-Bernstein, David Kanter, and Sanjay Kaul
Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis
December, 2015
By Deirdre K Tobias, Mu Chen, JoAnn E Manson, David S Ludwig, Walter Willett, Frank B Hu
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years
November, 2020
By David Unwin, Ali Ahsan Khalid, Jen Unwin, Dominic Crocombe, Christine Delon, Kathy Martyn, Rajna Golubic, Sumantra Ray
Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial
June, 2019
By Shaminie J Athinarayanan, Rebecca N Adams, Sarah J Hallberg, Amy L McKenzie, Nasir H Bhanpuri, Wayne W Campbell, Jeff S Volek, Stephen D Phinney, James P McCarter
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
March, 2018
By a large panel of authors
Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study
May, 2018
By Nasir H Bhanpuri, Sarah J Hallberg, Paul T Williams, Amy L McKenzie, Kevin D Ballard, Wayne W Campbell, James P McCarter, Stephen D Phinney, Jeff S Volek
Effect of a 90 g/day low-carbohydrate diet on glycaemic control, small, dense low-density lipoprotein and carotid intima-media thickness in type 2 diabetic patients: An 18-month randomised controlled trial
October, 2020
By Chin-Ying Chen, Wei-Sheng Huang, Hui-Chuen Chen, Chin-Hao Chang, Long-Teng Lee, Heng-Shuen Chen, Yow-Der Kang, Wei-Chu Chie, Chyi-Feng Jan, Wei-Dean Wang, Jaw-Shiun Tsai
Comparison of Low Fat and Low Carbohydrate Diets on Circulating Fatty Acid Composition and Markers of Inflammation
February, 2008
By Cassandra Forsythe, Stephen Phinney, Maria Luz Fernandez, Erin E Quann
Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC State-of-the-Art Review
April, 2021
By Salva R Yurista, Cher-Rin Chong, Juan J Badimon, Daniel P Kelly, Rudolf A de Boer, B Daan Westenbrink
A Ketogenic Diet Is Protective Against Atherosclerosis in Apolipoprotein E Knockout Mice
June, 2020
By Courtney Whalen, Floyd Mattie, Elisabeth Bach, Teodoro Bottiglieri, A Catharine Ross, Thomas Neuberger, and Rita Castro1
Ketogenic diet in the treatment of cancer - Where do we stand?
March, 2020
By Daniela D Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G Feichtinger, Barbara Kofler
Ketogenic Diet in Alzheimer's Disease
August, 2019
By Marta Rusek, Ryszard Pluta, Marzena Ułamek-Kozioł, Stanisław J Czuczwar
Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease)
January, 2019
By Dariusz Włodarek
Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer's Disease
January, 2019
By Jason Brandt, Alison Buchholz, Bobbie Henry-Barron, Diane Vizthum, Dimitrios Avramopoulos, Mackenzie C Cervenka
Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease
February, 2021
By Matthew C L Phillips, Laura M Deprez, Grace M N Mortimer, Deborah K J Murtagh, Stacey McCoy, Ruth Mylchreest, Linda J Gilbertson, Karen M Clark, Patricia V Simpson, Eileen J McManus, Jee-Eun Oh, Satish Yadavaraj, Vanessa M King, Avinesh Pillai, Beatriz Romero-Ferrando, Martijn Brinkhuis, Bronwyn M Copeland, Shah Samad, Shenyang Liao, Jan A C Schepel
Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease
December, 2017
By Matthew K Taylor, Debra K Sullivan, Jonathan D Mahnken, Jeffrey M Burns, Russell H Swerdlow
Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial
August, 2019
By Robert Krikorian, Marcelle D. Shidler, Suzanne S. Summer, Patrick G. Sullivan, Andrew P. Duker, Richard S. Isaacson, and Alberto J. Espay
Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial
August, 2018
By Matthew C L Phillips, Deborah K J Murtagh, Linda J Gilbertson, Fredrik J S Asztely, Christopher D P Lynch
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study
February, 2005
By T B Vanitallie, C Nonas, A Di Rocco, K Boyar, K Hyams, S B Heymsfield
5. Integrating Metabolic Strategies into Healthcare
5.1 Interpreting Evidence
Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal
April, 2008
By Anthony Accurso, Richard K Bernstein, Annika Dahlqvist, Boris Draznin, Richard D Feinman, Eugene J Fine, Amy Gleed, David B Jacobs, Gabriel Larson, Robert H Lustig, Anssi H Manninen, Samy I McFarlane, Katharine Morrison, Jørgen Vesti Nielsen, Uffe Ravnskov, Karl S Roth, Ricardo Silvestre, James R Sowers, Ralf Sundberg, Jeff S Volek, Eric C Westman, Richard J Wood, Jay Wortman, Mary C Vernon
5.2 Financial Incentives
Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study
January, 2017
By Rosa Ahn, Alexandra Woodbridge, Ann Abraham, Susan Saba, Deborah Korenstein, Erin Madden, W John Boscardin, Salomeh Keyhani
Industry sponsorship and research outcome: systematic review with meta-analysis
October, 2018
By Andreas Lundh, Joel Lexchin, Barbara Mintzes, Jeppe B Schroll, Lisa Bero
Full Text Open Access Article
Reporting of financial conflicts of interest by Canadian clinical practice guideline producers: a descriptive study
June, 2020
By Katharine Elder, Kimberly A Turner, Lisa Cosgrove, Joel Lexchin, Adrienne Shnier, Ainsley Moore, Sharon Straus, Brett D Thombs
Financial Conflicts of Interest at FDA Drug Advisory Committee Meetings
March, 2018
By Michael J Hayes, Vinay Prasad
Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine
March, 2021
By Jonathan Hinton, Thomas Reeves, Benoy N Shah
5.3 Healthcare Education
5.4 Patient Adherence
6. Conclusions
