Open Future HealthThe Role of Fatty Acids in Your Body

Fatty acids yield the most energy for metabolism, on an energy per gram basis.

Fatty acids (mainly in the form of triglycerides) are the foremost storage form of fuel in most animals.


When you eat saturated fat, it's turned into fatty acids, which, in the absence of insulin, become acetyl-CoA, and CAN"T become fat in your body. The fat you eat can't become glucose (there are some tiny exceptions). The fat you eat stops you feeling hungry.

The Role of Fatty Acids in Your Body

Fat Metabolism

Local FileKetones are a beneficial product of dietary fat metabolism in the body. When carbohydrate intake is restricted, that action lowers blood sugar and insulin levels. As insulin levels fall and energy is needed, fatty acids flow from the fat cells into the bloodstream and are taken up by various cells and Local Filemetabolized in a process called beta-oxidation.

The end result of beta-oxidation is a molecule called acetyl-coA, and as more fatty acids are released and metabolised, acetyl-coA levels in the cells rise. This causes a sort of metabolic "feedback loop" which triggers liver cells to shunt excess acetyl-Coa into ketogenesis, or the making of ketone bodies.

Once created, the liver dumps the ketone bodies into the blood stream, and they are taken up by skeletal and heart muscle cells at rates of availability. In addition, the brain begins to use ketones as an alternate fuel. That is why everyone can benefit from a Local FileKetogenic diet. Local FileNutritional ketosis is a possible Local Filelifestyle option for each of us.

Energy Production

One role of fatty acids within human Local Filemetabolism is energy production, captured in the form of adenosine triphosphate (ATP).

When compared to other macro-nutrient classes (Local Filecarbohydrates and Local Fileprotein), fatty acids yield the most adenosine triphosphate (ATP) on an energy per gram basis, when they are completely oxidized to CO2 and water by ß-oxidation and the citric acid cycle.

Fatty acids mobilized from triacylglycerols are oxidized to meet the energy needs of a cell or organism. They are the foremost storage form of fuel in most animals, and to a lesser extent in plants.

Long-chain fatty acids cannot cross the blood–brain barrier and so cannot be used as fuel by the cells of the central nervous system; but medium-chain fatty acids octanoic acid and heptanoic acid can be used, in addition to glucose and ketone bodies.

The processes of fatty acid synthesis (preparation for energy storage) and fatty acid degradation (preparation for energy use) are, in many ways, the reverse of each other.


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